16985-03-8

Nonabine (BRL-4664), a cannabinoid, is a antiemetic agent. Nonabine activates CB1 receptor in the brainstem and enteric nervous system[1][2].

CB1

[1] Archer CB, et al. Antiemetic effect of nonabine in cancer chemotherapy: a double blind study comparing nonabine and chlorpromazine. Br Med J (Clin Res Ed). 1983 Jan 29;286(6362):350-1. DOI:10.1136/bmj.286.6362.350-a
[2] Shah S, et al. ASRA Pain Medicine consensus guidelines on the management of the perioperative patient on cannabis and cannabinoids. Reg Anesth Pain Med. 2023 Mar;48(3):97-117. DOI:10.1136/rapm-2022-104013