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Otosenine is a natural pyrrolizidine alkaloid. Otosenine can be isolated from the aerial parts of the golden ragwort, Senecio aureus. Otosenine has spasmolytic and hypotensive properties[1][2].

ChEBI: Otosenine is a pyrrolizine alkaloid that is produced by several Jacobaea and Senecio species. It has a role as a Jacobaea metabolite. It is a macrocyclic lactone, a tertiary amino compound, a tertiary alcohol, a pyrrolizine alkaloid, an organic heterobicyclic compound, a spiro-epoxide and an enone.

[1] Resch J F, et al. Otosenine from Senecio aureus[J]. Planta medica, 1983, 47(04): 255-255.
[2] Lee S, et al. Isolation and biological activity of azocine and azocane alkaloids. Bioorg Med Chem. 2022 Jan 15;54:116560. DOI:10.1016/j.bmc.2021.116560