Description
ZM 253270 is a new class of nonpeptide neurokinin A antagonist.
Uses
ZM 253270 is a species-selective non-peptide NK-2 receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [3H]NKA to native or cloned NK-2R from hamster bladder (Ki=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [3H]NKA to cloned human NK-2R[1].
IC 50
Hamster Bladder NK-2: 2 nM (Ki)
References
[1] Aharony D, et al. Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274(3): 1216-1221. PMID:7562491
