168425-64-7

Compound 401 is a selective inhibitor of DNA-PK and FRAP.

Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC 50 values are 0.28 and 5.3 μ M respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC 50 values are all > 100 μ M). Induces apoptosis in vitro .

DNA-PK: 0.28 μM (IC₅₀); mTOR: 5.3 μM (IC₅₀)

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