1681020-60-9

Name	1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1)
CAS	1681020-60-9
Molecular Formula	C23H24ClFN4O2
Molecular Weight	442.92
MOL File	1681020-60-9.mol

Synonyms

IDX-1197 hydrochloride Venadaparib hydrochloride 1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1)

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Hazard Information

Uses

Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research[1][2].

in vivo

In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group^[1].

IC 50

PARP1: 1.4 nM (IC₅₀); PARP2: 1 nM (IC₅₀)

References

[1] Yong Man Kim, et al. First-in-human dose-finding study of venadaparib (IDX-1197), a potent and selective PARP inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology. 39, no. 15_suppl (May 20, 2021) 3107-3107.
[2] Jae-Hoon Kang, et al. A novel phtalazinone derivatives and manufacturing process thereof. WO2015037939A1.

Supplier

Bide Pharmatech Ltd.

Telephone400-1647117 13681763483

Websitehttps://www.bidepharm.com/

Shanghai Merlot Chemical Co., LTD

Telephone 15821661757

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1059485/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Weijiahe Biotechnology Co., Ltd

Telephone17502176150; 17502176150

Website

Shanghai Anbida Biotechnology Co., Ltd.

Telephone021-61629020 18201956406

Websitehttps://www.ambeed.cn/

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