16606-55-6

4254-14-2

105-58-8

16606-55-6

The general procedure for the synthesis of R-propylene carbonate from (R)-1,2-propanediol and diethyl carbonate was as follows: (R)-1,2-propanediol (38.05 kg, 500 mol) was added to a glass-lined reactor, followed by the addition of diethyl carbonate (70.88 kg, 600 mol) and sodium ethoxide (3.4 kg, 50 mol). The reaction mixture was heated to 105-110 °C and maintained for 8 hours. After completion of the reaction, unreacted diethyl carbonate was removed by distillation under reduced pressure. After the reaction mixture was cooled to room temperature, the insoluble material was removed by filtration. Finally, the solvent was removed by evaporation of the filtrate to afford R-propylene carbonate (34.24 kg, purity ≥99%) in 90% yield.