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BIBU-1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that blocks downstream EGFR signaling events such as MAPKK/MAPK activation.

BIBU (BIBU-1361) caused increased LC3-I to LC3-II conversion and triggered the internalization of EGFR within vacuoles along with its increased co-localization with LC3-II. BIBU caused accumulation of p62 and increased levels of cleaved forms of Beclin-1 in all the cell lines tested._x000D_ _x000D_ Reference: Mol Carcinog. 2013 Dec;52(12):970-82. https://pubmed.ncbi.nlm.nih.gov/22753156/

Selective inhibitor of EGFR-kinase.