ChemicalBook CAS DataBase List 1640247-87-5

1640247-87-5

Chemical Properties

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Animal Model:	Female Lewis rats with established collagen-induced arthritis (CIA)^[1].
Dosage:	0.3 mg/kg, 1 mg/kg, and 3 mg/kg.
Administration:	Orally, twice-daily for 7 days starting on the 10th day after the second collagen immunization.
Result:	Demonstrated significant reduction in ankle swelling in rats treated with 0.3 mg/kg 35 (31% reduction), 1 mg/kg 35 (67%), and 3 mg/kg 35 (65%). Plasma concentrations measured on day 7 (12 h after last dose) were consistent with maintaining approximately 60%, 80%, and >90% inhibition of PI3Kδ at 0.3, 1.0, and 3 mg/kg doses, respectively, at trough levels.