ChemicalBook CAS DataBase List 1638644-62-8

1638644-62-8

Name	6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride
CAS	1638644-62-8
Molecular Formula	C16H15ClN4O2
Molecular Weight	330.77
MOL File	1638644-62-8.mol

Chemical Properties

Boiling point	501.7±50.0 °C(Predicted)
density	1.48±0.1 g/cm3(Predicted)
storage temp.	Desiccate at RT
solubility	Soluble in DMSO
form	Solid
pka	4.79±0.20(Predicted)
color	White to off-white

Safety Data

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Hazard Information

Spectrum Detail

Supplier

Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Shanghai SuperLan Chemcial Technique Centre

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Shenzhen SUNGENING Bio-Medical Co., Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

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Fujian boshi pharmaceutical technology co. LTD

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Energy Chemical

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Beijing Stronger Science Co., Ltd.

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Bide Pharmatech Ltd.

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Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Xianning Shen Lan Biomedical Research and Development Co., Ltd.

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Shanghai Tachizaki Biomedical Research Center

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Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

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Wuhan Jingkangen Biomedical Technology Co., Ltd

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Nantong QuanYi Biotechnology Co., Ltd

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Animal Model:	C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis^[3]
Dosage:	6.25 mg/kg
Administration:	Intraperitoneal injection, 30 min prior to MDP
Result:	Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression.

1638644-62-8

Chemical Properties

Safety Data

Hazard Information

Uses

Biological Activity

in vivo

IC 50

storage

Spectrum Detail

Supplier