16378-22-6

Name	Piroheptine
CAS	16378-22-6
Molecular Formula	C22H25N.ClH
MDL Number	MFCD01688069
Molecular Weight	339.907
MOL File	16378-22-6.mol

Synonyms

Trimol Piroheptine HCl piroheptine hydrochloride Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methyl-, hydrochloride (8CI, 9CI)

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Chemical Properties

Melting point

250-253°

Safety Data

Toxicity

LD50 in male mice, rats (mg/kg): 153, 600 orally; 19, 17 i.v.; 95, 110 i.p.; 109, 330 s.c. (Hitomi)

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Hazard Information

Uses

Piroheptine hydrochloride is an anticholinergic agent to inhibit dopamine uptake. Piroheptine hydrochloride prevents loss of striatal dopamine induced by MPTP (HY-15608). Piroheptine hydrochloride can be used for research in Parkinson[1].

Definition

ChEBI: Piroheptine hydrochloride is the hydrochloride salt of piroheptine. It has a role as an antiparkinson drug and a muscarinic antagonist. It contains a piroheptine(1+).

in vivo

Piroheptine hydrochloride (20 mg/kg; ip; singel dose, 30 min before MPTP injection) suppresses neurotoxicity of MPTP in mice model^[1].

Animal Model:	Male 8-week-old C57BL/6J mice (20-30 g)^[1]
Dosage:	20 mg/kg
Administration:	IP; 30 min before MPTP injection (10 mg/kg; 4 times with 1 h interval)
Result:	Prevented loss of striatal dopamine.

References

[1] Saitoh T. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl. J Neurol Sci. 1988 Feb;83(2-3):161-6. DOI:10.1016/0022-510x(88)90065-2

Supplier

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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