162166-80-5

Name	L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]-
CAS	162166-80-5
Molecular Formula	C22H34N6O4S
Molecular Weight	478.61
MOL File	162166-80-5.mol

Synonyms

BMS189664 BMS-189664 BMS 189664 BMS189664,BMS 189664 L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]-

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Chemical Properties

density	1.41±0.1 g/cm3(Predicted)
pka	9.49±0.40(Predicted)

Hazard Information

Uses

BMS-189664 is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC50 of 0.046 μM. BMS-189664 can be used for arterial and venous thrombosis research[1].

in vivo

BMS-189664 is efficacious at protecting mice from thrombin-induced lethality^[1].
BMS-189664 (0.2 mg/kg, iv) inhibits arterial thrombosis in cynomolgus monkey models^[1].
BMS-189664 (infused at 9, 25, and 100 mg/kg/min for 1 h to achieve 0.5, 2, and 6 mg/kg) inhibits venous thrombosis in cynomolgus monkey models^[1].
The oral bioavailability of BMS-189664 based on the dose-normalized AUCs after oral and iv dosing was 15 and 17% in dogs and monkeys, respectively^[1].

References

[1] Das J, et al. Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. Bioorg Med Chem Lett. 2002 Jan 7;12(1):45-9. DOI:10.1016/s0960-894x(01)00667-9

Supplier

Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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