1616271-41-0

Name	Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-
CAS	1616271-41-0
Molecular Formula	C16H15Cl2NO3
Molecular Weight	340.2
MOL File	1616271-41-0.mol

Synonyms

CCTA-1523 Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-

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Chemical Properties

Boiling point	498.5±45.0 °C(Predicted)
density	1.313±0.06 g/cm3(Predicted)
pka	11.00±0.70(Predicted)

Hazard Information

Description

CCTA-1523 is an inhibitor of the efflux function of ABCG2. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells, both in vitro and in vivo.

Uses

CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity[1].

in vivo

CCTA-1523 (75 mg/kg; p.o.; q3d x 6) combined with doxorubicin (HY-15142A) (1.8 mg/kg, i.p., q3d X 6) inhibits tumor growth and increases the survival time in mice^[1].

Animal Model:	NCR nude mice (H460/MX20 xenografts)^[1]
Dosage:	75 mg/kg (DOX ;1.8 mg/kg, i.p., q3d X 6)
Administration:	P.o.;q3d x 6
Result:	Significantly inhibited the growth of H460/MX20 tumor xenografts when combined with doxorubicin compared to the vehicle control group.

References

[1] Patel A,et al. Suppression of ABCG2 mediated MDR in vitro and in vivo by a novel inhibitor of ABCG2 drug transport. Pharmacol Res. 2017 Jul;121:184-193. DOI:10.1016/j.phrs.2017.04.025

Spectrum Detail

Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-(1616271-41-0)¹HNMR

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Sangon Biotech (Shanghai) Co.,Ltd.

Telephone400-821-026

Websitehttp://www.sangon.com

Shanghai Amole Biotechnology Co., Ltd.

Telephone18916360931 18916360931

Websitehttps://www.amole.com.cn/

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