161258-30-6

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• Skin Benifits

  Pentamide-6, or Hexapeptide-11, was originally isolated from Saccharomyces yeast fermentation. Pentamide-6 directly affects dermal cell senescence by downregulating key genes involved in apoptosis. The cellular proteins ataxia telangiectasia mutated (ATM) and p53 have been shown to be hyperactive in degenerative aging pathologies, leading to cellular senescence. Senescent cells in skin can cause dermal thinning, loss of subcutaneous fat, decreased hair growth, and slower wound healing. Pentamide-6 is a hexapeptide with the structure Phe-Val-Ala-Pro-Phe-Pro (FVAPFP). This oligopeptide helps promote younger looking skin by reversibly downregulating ATMP and p53 at peptide concentrations of 0.1%–1.0%. By targeting the cellular aging process, FVAPFP has been shown to modulate senescence in both intrinsically and extrinsically aged fibroblasts, as well as extrinsically aged dermal papillae cells in vitro. This signal oligopeptide has been shown to increase fibrillogenesis through growth factors, and ECPs increase transmembrane and cell shock proteins, and promote hair growth. A clinical trial conducted on 25 subjects showed its ability to increase skin elasticity and reduce deformity in facial skin.;

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