1609071-04-6

1609071-03-5

1609071-04-6

The general procedure for the synthesis of 5,6-bis((4-methoxybenzyl)oxy)isobenzofuran-1,3-dione, using the compound (CAS:1609071-03-5) as starting material, was as follows: compound 1d (42.71 g, 79 mmol) was suspended in acetone (350 mL). Jones reagent (2.67 mol/L, 71.0 mL, 190 mmol) was added slowly at 0 °C. The reaction mixture was stirred continuously at 0°C for 1 hour. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and water, followed by quenching by addition of sodium bisulfite at 0 °C. The organic phase was separated, washed sequentially with water and saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration to remove the desiccant, the filtrate was concentrated under reduced pressure. The precipitated solid product was collected by filtration and washed with diisopropyl ether to give the final compound 1e (26.94 g, 81% yield).