1586767-92-1

PHA-543613 hydrochloride is an oral or active α7 nAChR agonist with brain permeability, For α3β4, α1β1γδ, α4β2 and 5-HT3 receptors selective. PHA-543613 hydrochloride affects sensory gating and memory in an in vivo model of schizophrenia[1][1].

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[1] Faghih R, et al. Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. J Med Chem. 2008 Feb 28;51(4):701-12. DOI:10.1021/jm070256g
[2] Wishka DG, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13;49(14):4425-36. DOI:10.1021/jm0602413