Description
2C-N is described formally as 2,5-dimethoxy-4-nitrophenethylamine and is structurally analogous to the psychedelic drug 2C-B . 2C-N potently stimulates arachidonic acid release through the serotonin receptors 5-HT2C (pEC50 = 5.91) and 5-HT2A (pEC50 = 4.78). 25N-NBOMe is a derivative of 2C-N having an N-(2-methoxybenzyl) addition at the amine. For similar dimethoxyphenethylamines including 2C-B, this N-(2-methoxybenzyl) addition significantly increases activity at the serotonin receptor. This product is intended for forensic and research uses.
Uses
25N-NBOMe Hydrochloride is an analog of 25N-NBOMe, a designer drug in the NBOMe category, which is a psychoactive substance associated with abuse and toxicity and has been detected using LC-HRMS in urine samples
IC 50
5-HT2A Receptor: 0.144 nM (Ki); 5-HT2C Receptor: 1.06 nM (Ki); 5-HT2B Receptor: 8.7 nM (Ki); 5-HT1A Receptor: 2260 nM (Ki); 5-HT2A Receptor: 0.51 nM (EC50); 5-HT2C Receptor: 1.32 nM (EC50); 5-HT2B Receptor: 47 nM (EC50); 5-HT1A Receptor: 4800 nM (EC50)
References
[1] ANDERS ETTRUP. Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET.[J]. Journal of Nuclear Medicine, 2010, 51 11: 1763-1770. DOI:
10.2967/jnumed.109.074021
