155614-01-0

IR-1061 exhibits excellent performance in in vivo imaging experiments on mice. Bimodal imaging is performed by a single injection of the PLP-D probe containing IR-1061. In OTN-NIR imaging, signals can be observed 30 seconds after injection. Blood vessels and the liver are visualized first, and the signals remains stable within 300 seconds after injection. Most of the signals accumulates in the liver and spleen 150 minutes later. In MRI, imaging startes 30 minutes after injection, and signal changes in regions such as the liver and bladder can be observed^[1].