155471-10-6

JWH 007 is a potent cannabinoid (CB) receptor agonist that avidly binds to both CB₁ and CB₂ (K_i = 9.5 and 2.9 nM, respectively). This compares favorably with the binding of Δ⁹-THC, which binds CB₁ and CB₂ with K_i values of 41 and 36 nM, respectively. Similarly, JWH 007 performs comparably to Δ⁹-THC in mouse studies on spontaneous activity, antinociception, hypothermia, and catalepsy.

Isotope labelled JWH-007 is a novel cannabinoid receptor agonist at both the CB1 and CB2 receptors.

[1] JOHN W. HUFFMAN ?. Design, Synthesis and Pharmacology of Cannabimimetic Indoles[J]. Bioorganic & Medicinal Chemistry Letters, 1994, 4 4: Pages 563-566. DOI: 10.1016/s0960-894x(01)80155-4