154436-48-3

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC (SAPC; ) by 15-lipoxygenase (15-LO).¹ 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is toxic to human umbilical vein endothelial cells (HUVECs) when used at a concentration of 100 μM.²

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC (15(S)-HpETE-SAPC) is a compound studied for the cytotoxicity of phosphatidylcholine hydroperoxides. Its cytotoxicity is exerted through the decomposition of hydroperoxides to produce toxic compounds.

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1. Morgan, A.H., Hammond, V.J., Morgan, L., et al. Quantitative assays for esterified oxylipins generated by immune cells Nat. Protoc. 5(12),1919-1931(2010).
2. Kaneko, T., Baba, N., and Matsuo, M. Cytotoxicity of phosphatidylcholine hydroperoxides is exerted through decomposition of fatty acid hydroperoxide moiety Curr. Opin. Struct. Biol. 21(2),173-179(1996).