1502816-23-0

MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells[1].

MS049 is a potent and selective inhibitor of protein arginine methyltransferases (PRMTs) PRMT 4 and PRMT6. MS049 is active in cells. For full characterization detailsplease visit the MS049 probe summary on the Structural Genomics Consortium (SGC) website.

MS049N is the negative control for the active probeMS049. To request a sample of the negative control from the SGCclick here.

To learn about other SGC chemical probes for epigenetic targetsvisit sigma.com/sgc

PRMT4: 34 nM (); PRMT6: 43 nM (); PRMT8: 1600 nM ()

[1] Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Sep 15. DOI:10.1021/acs.jmedchem.6b01033