150208-28-9

The novel σ receptor ligands

σ 1 receptor antagonist, approximately 50-fold selective over σ 2 sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine, α 1 , α 2 , β adrenoceptor, 5-HT 1 and 5-HT 2 receptors. Prevents hyperlocomotion following cocaine administration in mice.