149859-17-6

Name	MDL 101146
CAS	149859-17-6
Molecular Formula	C29H37F5N4O6
MDL Number	MFCD00918032
Molecular Weight	632.62
MOL File	149859-17-6.mol

Synonyms

146 MD 101 MDL 101 MDL-101 MD 101,146 MDL 101146 L-Prolinamide, N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N-[3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]- (9CI)

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Hazard Information

Uses

MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].

in vivo

MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis^[2].

Animal Model:	Rats^[2]
Dosage:	200 mg/kg
Administration:	Oral, 200 mg/kg/day
Result:	Inhibited the severity of collagen-induced arthritis. Had a bone and cartilage sparing effect in the tibio-tarsal joint of animals with collagen-induced arthritis.

References

[1] Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl DOI:10.1021/jm00052a013
[2] M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46(12):503-8. DOI:10.1007/s000110050233

Supplier

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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