14919-77-8

Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA (Item No. 13248) to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.

White Crystalline Solid

Antiparkinsonian;DOPA decarboxylase inhibitor

Used as antiparkinsonian. A peripheral decarboxylase inhibitor

ChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions whe given alone.

Inhibitor of L-aromatic amino acid decarboxylase.