149-44-0

Name	RONGALITE
CAS	149-44-0
EINECS(EC#)	205-739-4
Molecular Formula	CH3NaO3S
MDL Number	MFCD00040426
Molecular Weight	118.09
MOL File	149-44-0.mol

Chemical Properties

Appearance	solid
Melting point	~120 °C (dec.)
density	1.744[at 20℃]
vapor pressure	0.003Pa at 20℃
Fp	>100℃
storage temp.	Inert atmosphere,Room Temperature
solubility	H₂O: 50 mg/mL, clear, colorless
form	Solid
color	White to Off-White
PH	9.5-10.5
Stability:	Stable. Incompatible with strong oxidizing agents.
Water Solubility	soluble H2O, alcohol [HAW93]
Merck	8620
EPA Substance Registry System	Sodium sulfoxylate formaldehyde (anhydrous) (149-44-0)

Safety Data

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-68-31 less more
Safety Statements	26-36-36/37 less more
WGK Germany	1
RTECS	PB0380000
TSCA	Yes
Hazardous Substances Data	149-44-0(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

Chemical Properties

solid

Uses

Pharmaceutic aid (preservative).

Production Methods

Sodium formaldehyde sulfoxylate is manufactured from sodium dithionate and formaldehyde in water.

Purification Methods

It crystallises from H2O as the dihydrate and decomposes at higher temperatures. Store it in a closed container in a cool place. It is insoluble in EtOH and Et2O and is a good reducing agent. [X-ray structure: Tuter J Chem Soc 3064 1955.] Note that this compound {HOCH2SO2Na} should not be confused with formaldehyde sodium bisulfite adduct {HOCH2SO3Na} from which it is prepared by reduction with Zn. [Beilstein 1 IV 3052.]

Flammability and Explosibility

Nonflammable

Pharmaceutical Applications

Sodium formaldehyde sulfoxylate is a water-soluble antioxidant and is generally used as the dihydrate. It is used in the formulation of injection products at a level of up to 0.1% w/v in the final preparation administered to the patient.

Safety

The toxicological properties of sodium formaldehyde sulfoxylate have not been fully investigated. However, it is used in the formulation of injection products at a level to 0.1% w/v in the final preparation administered to the patient.
Sodium formaldehyde sulfoxylate is moderately toxic by ingestion, and when heated to decomposition it emits toxic fumes of sulfur dioxide and sodium oxide.
LD50 (mouse, oral): 4 g/kg
LD50 (rat, IP): >2 g/kg
LD50 (rat, oral): >2 g/kg

storage

Store in well-closed, light-resistant containers at controlled room temperature (15–30℃).

Incompatibilities

Sodium formaldehyde sulfoxylate is incompatible with strong oxidizing agents; it is decomposed by dilute acid.

Regulatory Status

Included in the FDA Inactive Ingredients Database (parenteral products up to 0.1% via the IM, IV, and SC routes). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Spectrum Detail

Supplier

J & K SCIENTIFIC LTD.

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Chengdu Ai Keda Chemical Technology Co., Ltd.

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Shanghai civi chemical technology co.,Ltd

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Shanghai T&W Pharmaceutical Co., Ltd.

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9ding chemical ( Shanghai) Limited

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