148296-46-2

GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1].

Intermediate in fructose and mannose metabolism, ascorbate and aldarate metabolism, amino sugar and nucleotide sugar metabolism and N-Glycan biosynthesis.

Human Endogenous Metabolite

[1] Elling L, et al. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Glycobiology. 1996 Sep;6(6):591-7. DOI:10.1093/glycob/6.6.591