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148-82-3

Name Melphalan
CAS 148-82-3
EINECS(EC#) 205-726-3
Molecular Formula C13H18Cl2N2O2
MDL Number MFCD00057717
Molecular Weight 305.2
MOL File 148-82-3.mol

Chemical Properties

Appearance Melphalan forms solvated crystals from methanol.
Melting point  ~180 °C
alpha  D25 +7.5° (c = 1.33 in 1.0N HCl); D22 -31.5° (c = 0.67 in methanol)
Boiling point  473.1±45.0 °C(Predicted)
density  1.3587 (rough estimate)
refractive index  1.6070 (estimate)
storage temp.  -20°C Freezer
solubility  95% ethanol and 1 drop 6 N HCl: 0.05 g/mL, clear
form  powder
pka pKa 1.42/2.75/9.17(H2O,t =37.0,I=0.5) (Uncertain)
color  white
Water Solubility  <0.1 g/100 mL at 22 ºC
Usage Antineoplastic
Merck  13,5850
BRN  2816456
InChIKey SGDBTWWWUNNDEQ-LBPRGKRZSA-N
CAS DataBase Reference 148-82-3(CAS DataBase Reference)
IARC 1 (Vol. 9, Sup 7, 100A) 2012
EPA Substance Registry System 148-82-3(EPA Substance)

Safety Data

Hazard Codes  T+
Risk Statements 
R45:May cause cancer.
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R63:Possible risk of harm to the unborn child.
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  AY3675000
8
HazardClass  6.1(a)
PackingGroup  II
HS Code  29224999
Safety Profile
Confirmed human carcinogen producing leukemia and Hodgkin's disease. Poison by ingestion, intravenous, and intracerebral routes. Human systemic effects by ingestion: nausea, hypermothty, diarrhea, agranulocytosis, thrombocytopenia. Human reproductive effects by ingestion: menstrual changes. Mutation data reported. A skin irritant. Used as a poison gas. When heated to decomposition it emits toxic fumes of ClandNOx.
Hazardous Substances Data 148-82-3(Hazardous Substances Data)
Toxicity
LD50 i.p. in rats: 14.7 mmol/kg (Ross)

Hazard Information

Material Safety Data Sheet(MSDS)

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