GAT107 (compound 1b) is a potent α7 nAChR ago-PAMs (positive allosteric modulators)[1].
References
[1] Thakur GA, et al. Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotinic acetylcholine receptors. J Med Chem. 2013 Nov 14;56(21):8943-7. DOI:10.1021/jm401267t
