147591-46-6

ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2

Enables the long term expansion of embryonic stem cells (ESC) without the addition of MEF, LIF, and FBS while retaining pluripotency. ESC's treated with ID-8 in a serum-free medium consistently differentiated into many cell types, including neurons, muscle cells and hepatocytes. Stimulates proliferation at a steady rate.

ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).

ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).

+4°C

1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242 2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18