147340-43-0

Name	MHP 133
CAS	147340-43-0
Molecular Formula	C17H20ClN5O3
MDL Number	MFCD00942058
Molecular Weight	377.83
MOL File	147340-43-0.mol

Synonyms

MHP 133

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Chemical Properties

storage temp.	Store at -20°C
solubility	Soluble in DMSO

Hazard Information

Uses

MHP 133 is a agent with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.

in vivo

In rats, MHP-133 (50, 100, or 200 μg/kg, i.p.) enhances acquisition of the task and increases task accuracy. MHP-133 elicits significant improvements in task accuracies during sessions initiated 10 min after dosing^[1].

IC 50

mAChR1; mAChR2; 5-HT₄ Receptor; AChE: 69 μM (Ki)

References

[1] Buccafusco JJ, et al. MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition. Neurochem Res. 2007 Jul;32(7):1224-37. Epub 2007 Apr 3. DOI:10.1007/s11064-007-9294-0

Supplier

Beijing xinyanhui pharmaceutical research and development co., LTD

Telephone 13969155946

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList710437/0_EN.htm

cjbscvictory

Telephone13348960310 13348960310

Websitehttps://www.weikeqi-biotech.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

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