146552-71-8

General procedure for the synthesis of tert-butyl (S)-(1-aminopropan-2-yl)carbamate from the compound (CAS: 146610-69-7): Pd/C (10%, 2 g) was added to a solution of tert-butyl (S)-1-azidopropan-2-ylcarbamate (75.0 g, 0.375 mol) in methanol (1 L). The suspension was stirred at room temperature under hydrogen atmosphere for 4 hours. After completion of the reaction, the reaction mixture was filtered and the solid was washed with methanol (100 mL). The combined filtrates were concentrated under vacuum to afford tert-butyl (S)-1-aminopropan-2-ylcarbamate (65.1 g, quantitative yield), which was used directly in the next step without further purification.1H NMR (300 MHz, CDCl3) δ ppm: 4.64 (br s, 1H), 3.64 (m, 1H), 2.75 (dd, J = 13.2, 5.1 Hz, 1H), 2.63 (dd, J = 13.2, 6.6 Hz, 1H), 1.45 (s, 9H), 1.31 (br s, 2H), 1.12 (d, J = 6.6 Hz, 3H).

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