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14611-52-0

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Identification

Name
Selegiline hydrochloride
CAS
14611-52-0
Synonyms
D-(+)-DEPRENYL HYDROCHLORIDE
DEPRENYL HYDROCHLORIDE
L-DEPRENYL HYDROCHLORIDE
N,ALPHA-DIMETHYL-N-2-PROPYNYL-BENZENEETHANAMINE HYDROCHLORIDE
R(-)-DEPRENYL HCL
(R)-(-)-DEPRENYL HYDROCHLORIDE
R(-)-N-ALPHA-DIMETHYL-N-2-PROPYNYL-BENZENEETHANAMINE HYDROCHLORIDE
R-(-)-N,ALPHA-DIMETHYL-N-[2-PROPYNYL]PHENETHYLAMINE, HCL
(r)-(-)-n,alpha-dimethyl-n-(2-propynyl)phenethylamine hydrochloride
SELEGILINE
SELEGILINE HCL
SELEGILINE HYDROCHLORIDE
(-)-(r)-n,alpha-dimethyl-n-2-propynylphenethylaminemonohydrochloride
(-)-phenylisopropylmethylpropynylamine
eldepryl
fpf1100
jumex
n,alpha-dimethyl-n-2-propynyl-,hydrochloride,(r)-benzeneethanamin
Selegiline hydrochloride USP24
R(-)-DEPRENYL HYDROCHLORIDE (SELEGILINE) SELECTIVE MAO-B INHIB
EINECS(EC#)
604-508-9
Molecular Formula
C13H18ClN
MDL Number
MFCD00069299
Molecular Weight
223.74
MOL File
14611-52-0.mol

Chemical Properties

Appearance
Crystalline Solid
Melting point 
141-142°C
mp 
141-142°C
alpha 
D25 -10.8° (c = 6.48 in water)
storage temp. 
2-8°C
solubility 
H2O: >10 mg/mL

form 
solid

color 
white

optical activity
[α]25/D 10.8°, c = 6.48 in H2O(lit.)
Water Solubility 
Soluble in water at 100mM
Usage
Monoamine oxidase-B inhibitor related structurally to Pargyline. Used to alleviate the symptonms of Parkinsons disease
CAS DataBase Reference
14611-52-0(CAS DataBase Reference)

Safety Data

Safety Statements 
S22:Do not breathe dust .
S36:Wear suitable protective clothing .
RIDADR 
3249
WGK Germany 
3

RTECS 
DA0292500

HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2921490002
Hazardous Substances Data
14611-52-0(Hazardous Substances Data)
Toxicity
LD50 in rats (mg/kg): 81 i.v., 280 s.c. (Magyar)

Hazard Information

Chemical Properties
Crystalline Solid
Uses
antibacterial
Uses
Antidepressant, Antiparkinsonian
Uses
Selegiline hydrochloride is used to alleviate the symptonms of Parkinsons disease
Brand name
Eldepryl (Somerset); Zelapar (Valeant).
Biological Activity
Selective inhibitor of monoamine oxidase B (MAO-B).
Veterinary Drugs and Treatments
Selegiline is approved for use in dogs for the treatment of Cushing’s disease and for Canine Cognitive Dysfunction (so-called “old dog dementia”). Its use for Cushing’s disease is somewhat controversial as clinical studies evaluating its efficacy have shown disappointing results. In humans, selegiline’s primary indication is for the adjunctive treatment of Parkinson’s disease.

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