146-04-3

Name	Oosponol
CAS	146-04-3
Molecular Formula	C11H8O5
MDL Number	MFCD01718127
Molecular Weight	220.18
MOL File	146-04-3.mol

Synonyms

Oosponol Lenzitin Brn 1287762 4-Glycolyl-8-hydroxyisocoumarin Isocoumarin, 4-glycolyl-8-hydroxy- 4-(1-Oxo-2-hydroxyethyl)-8-hydroxyisocoumarin 8-Hydroxy-4-(hydroxyacetyl)-1H-2-benzopyran-1-one

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Chemical Properties

Melting point	170 °C
Boiling point	485.930±45.00 °C(Press: 760.00 Torr)(predicted)
density	1.548±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	6.704±0.20(predicted)
LogP	0.789 (est)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338
Toxicity	LD50 oral in rat: 250mg/kg less more

Hazard Information

Uses

Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi[1][2].

in vivo

Oosponol (6.25 mg/kg, 3.1 mg/kg, ip, Once) can lower blood pressure in spontaneously hypertensive rats model^[1].

Animal Model:	Spontaneously hypertensive rats^[1]
Dosage:	6.25 mg/kg, 3.1 mg/kg
Administration:	Intraperitoneal injection, once.
Result:	The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm^[1].

Animal Model:	Spontaneously hypertensive rats^[1]
Dosage:	6.25 mg/kg, 3.1 mg/kg
Administration:	Intraperitoneal injection, once.
Result:	The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm.

References

[1] Umezawa H, et al.. Dopamine -hydroxylase inhibitor produced by Gloeophyllum striatum and its identity with oosponol. J Antibiot (Tokyo). 1972 Apr;25(4):239-42. DOI:10.7164/antibiotics.25.239
[2] Sonnenbichler J,et al. Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells. Eur J Biochem. 1997 May 15;246(1):45-9. DOI:10.1111/j.1432-1033.1997.t01-2-00045.x

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