1458674-25-3

IMP-1700 (1458674-25-3) is a potent inhibitor of the bacterial DNA double-strand break repair complex AddAB. It is capable of synergistic sensitization of methicillin-resistant staphylococcus aureus (MRSA) to ciprofloxacin (EC50?= 0.6nM).? IMP-1700 is an important new tool for exploring new treatment options for drug resistant bacteria.

IMP-1700 is an important tool for exploring new treatment options for drug resistant bacteria. A potent inhibitor of the bacterial DNA double-strand break repair complex AddAB.

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1) Lim?et al.?(2019),?Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus; Bioorg. Med. Chem.,?27?114962