145841-10-7

Name	Sch-42495 (racemate)
CAS	145841-10-7
Molecular Formula	C20H29NO4S2
MDL Number	MFCD00871139
Molecular Weight	411.58
MOL File	145841-10-7.mol

Synonyms

Sch-42495 (racemate) L-Methionine, N-[2-[(acetylthio)methyl]-3-(2-methylphenyl)-1-oxopropyl]-, ethyl ester

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Chemical Properties

Boiling point	597.3±50.0 °C(Predicted)
density	1.158±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	13.50±0.46(Predicted)

Hazard Information

Uses

SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354[1].

in vivo

SCH 42495 (30 mg/kg; oral gavage; twice daily) causes a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days^[2].
Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats^[2].
SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively^[1].

Animal Model:	Hypoxic rats^[2]
Dosage:	30 mg/kg
Administration:	Oral gavage; twice daily for 10 days
Result:	Caused a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy. Led to a decrease in cardiovascular remodelling secondary to chronic hypoxia.

storage

Store at -20°C

References

[1] Watkins RW, et al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68. DOI:10.1093/ajh/6.5.357
[2] Thompson JS, et al. Effects of the neutral endopeptidase inhibitor, SCH 42495, on the cardiovascular remodelling secondary to chronic hypoxia in rats. Clin Sci (Lond). 1994 Jul;87(1):109-14. DOI:10.1042/cs0870109

Supplier

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

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