1456542-69-0

BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.

BRD-7880 is a potent and highly specific inhibitor of Aurora Kinase B (AURKB) and Aurora Kinase C (AURKC), with IC50 values of 7 nM and 12 nM, respectively[1].

Aurora B: 7 nM (IC₅₀); Aurora C: 12 nM (IC₅₀); Aurora A: 2153 nM (IC₅₀)

[1] Yu C, et al. High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines[J]. Nature biotechnology, 2016, 34(4): 419-423.