ChemicalBook CAS DataBase List 1448754-43-5

1448754-43-5

Name	Eleclazine (hydrochloride)
CAS	1448754-43-5
Molecular Formula	C21H17ClF3N3O3
MDL Number	MFCD30377215
Molecular Weight	451.83
MOL File	1448754-43-5.mol

Chemical Properties

storage temp.	Store at -20°C
solubility	DMSO:100.0(Max Conc. mg/mL);221.32(Max Conc. mM)
form	Solid
color	White to off-white
InChI	InChI=1S/C21H16F3N3O3.ClH/c22-21(23,24)30-16-5-2-14(3-6-16)15-4-7-18-17(12-15)20(28)27(10-11-29-18)13-19-25-8-1-9-26-19;/h1-9,12H,10-11,13H2;1H
InChIKey	ZRYHNOXHGYUHFF-UHFFFAOYSA-N
SMILES	O=C1N(CCOC2=CC=C(C3C=CC(OC(F)(F)F)=CC=3)C=C12)CC1=NC=CC=N1.Cl

Hazard Information

Uses

Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias[1][2][3].

in vivo

Eleclazine (0.3 and 0.9 mg/kg; IV; infused over 15 minutes) reduces the incidence of epinephrine-induced ventricular premature beats and couplets, and shortens ventricular QT and atrial PTa intervals^[1].

Animal Model:	Male Yorkshire pigs (35.20 ± 0.46 kg; injected with epinephrine via a jugular vein)^[1]
Dosage:	0.3 and 0.9 mg/kg
Administration:	IV; infused over 15 minutes
Result:	Reduced the incidence of epinephrine-induced ventricular premature beats and couplets by 51% (from 31.3 ± 1.91 to 15.2 ± 5.08 episodes; P = 0.038) and the incidence of 3- to 7-beat ventricular tachycardia (VT) by 56% (from 10.8 ± 3.45 to 4.7 ± 3.12 episodes; P = 0.004). Shortened ventricular QT and atrial PTa intervals by 7%, and reduced atrial repolarization alternans and heterogeneity without attenuation of the inotropic response to catecholamine.

References

[1] Bacic D, et al. Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model. Heart Rhythm. 2017 Mar;14(3):448-454. DOI:10.1016/j.hrthm.2016.10.021
[2] Rajamani S et al. The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. Br J Pharmacol. 2016 Jul 23. DOI:10.1111/bph.13563
[3] Potet F, Egecioglu DE, Burridge PW, George AL Jr. GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Mol Pharmacol. 2020 Nov;98(5):540-547. DOI:10.1124/molpharm.120.000048

Spectrum Detail

Supplier

MQ (shanghai) Pharmaceuticals Co., Ltd.

Telephone 13761635123

Websitehttp://www.linyuepharm.com/

Haoyuan Chemexpress Co., Ltd.

Telephone021-58950125

Websitehttp://gb.chemexpress.com.cn

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 18916372613

Websitehttps://www.shyuanye.com

ShangHai Biochempartner Co.,Ltd

Telephone177-54423994 17754423994

Websitehttps://www.biochempartner.com

Beijing Solarbio Science & Tecnology Co., Ltd.

Telephone17801761073 18101056239

Websitehttp://www.solarbio.com

Shenzhen Regent Biochemical Technology Co., Ltd.

Telephone0755-85201366 18938635012

Websitehttp://www.regentsciences.com/

Fan De(Beijing) Biotechnology Co., Ltd.

Telephone 15911056312

Websitehttp://www.bio-fount.com/

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Telephone86-571-88216897,88216896 13588875226

Websitehttp://www.hzclap.com/en/

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Telephone 18818260767

Websitehttp://www.chemegen.com

Shanghai Luofa Biochemical Technology Co., Ltd.

Telephone021-51111890 15317326293

Websitehttps://www.molnova.cn/

Abmole Bioscience Inc.

Telephone 19821158099

Websitehttp://www.abmole.cn/

Bide Pharmatech Ltd.

Telephone400-1647117 13681763483

Websitehttps://www.bidepharm.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Beijing Boorsen Biotechnology Co., Ltd

Telephone400-901-9800 18611424007

Websitehttp://www.bioss.com.cn/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

Changsha Fuzhen Biotechnology Co.，LTD

Telephone15111215862 18229892877

Websitehttp://www.fuzhenbiochem.com/

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

1of4

Related Products

Send Inquriy