144092-66-0

A 39355 may specifically overcome multidrug resistance without the serious hypotensive effects associated with calcium antagonists.

A-39355 is a compound that can overcome multidrug resistance and has the activity of reversing multidrug resistance. A-39355 can enhance the cytotoxicity of antitumor compounds in multidrug-resistant cells, increase the accumulation of compounds in cells, inhibit the efflux of compounds, and compared with calcium antagonists, it has no serious hypotensive effect. Its activity may be unrelated to the ability to block calcium transport.

[1] Reversal of multidrug resistance by two novel indole derivatives PMID:1355008