1440209-96-0

BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC₅₀s = 36 and 120 nM, respectively). It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC₅₀s = 12, 9, 23, >33, >33, 13, and >33 μM, respectively). BRD73954 (10 μM) increases acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells.

BRD73954 is a small molecule inhibitor which has the ability to inhibit HDAC6 and HDAC8. Affects cell adhesion and mobility in cells.

HDAC6: 0.036 μM (IC₅₀); HDAC8: 0.12 μM (IC₅₀); HDAC2: 9 μM (IC₅₀); HDAC1: 12 μM (IC₅₀); HDAC3: 23 μM (IC₅₀)

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[1]. olson de, wagner ff, kaya t, et al. discovery of the first histone deacetylase 6/8 dual inhibitors. j med chem, 2013, 56(11): 4816-4820.