ChemicalBook CAS DataBase List 143113-45-5

143113-45-5

Name	BQ-3020
CAS	143113-45-5
Molecular Formula	C96H140N20O25S
MDL Number	MFCD00236977
Molecular Weight	2006.34
MOL File	143113-45-5.mol

Synonyms

BQ-3020 AC-LMDKEAVYFAHLDIIW M.W. 2006.35 C96H140N20O25S Acetyl-(Ala 11,15)-ET 1 (6-21) endothelin receptor antagonist AC-(ALA11,15)-ENDOTHELIN-1 (6-21) N-AC, ALA11,15-ENDOTHELIN 1, 6-21 ACETYL-(ALA11,15)-ENDOTHELIN-1 (6-21) ACETYL-(D-TRP16)-ENDOTHELIN-1 (16-21) N-ACETYL[ALA11,15]-ENDOTHELIN-1 (6-21) N-ACETYL-[ALA11,15]ENDOTHELIN-I (6-21) ENDOTHELIN-1(6-21), N-ACETYL-[ALA11,15]- Acetyl-(Ala11·15)-Endothelin-1 (6-21) BQ-3020 n-acetyl-[ala11,15]-endothelin 1 fragment 6-21 BQ-3020 ENDOTHELIN-1(6-21),N-ACETYL-(ALA 11, 15) SYNTHETIC >97% AC-LEU-MET-ASP-LYS-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP AC-LEU-MET-ASP-LYS-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP-OH 6-21-Endothelin 1 (swine reduced), N-acetyl-11-L-alanine-15-L-alanine- ACETYL-LEU-MET-ASP-LYS-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP-OH Acetyl-(Ala11·15)-Endothelin-1 (6-21) Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH

Chemical Properties

Boiling point	2125.8±65.0 °C(Predicted)
density	1.287±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M)
form	powder
pka	3.39±0.10(Predicted)
color	white
Sensitive	Light Sensitive
Sequence	Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
InChIKey	NUAGCEFLVCODRQ-KETPNHLCSA-N

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H312-H302-H332
Precautionary statements	P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501
WGK Germany	3
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 1 Inhalation Acute Tox. 1 Oral

Hazard Information

Uses

BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.

Biological Activity

BQ-3020a linear endothelin analogis a selective ETB endothelin receptor agonist.

in vivo

BQ-3020 (3 mg/kg for i.h., single dose) attenuates cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection in cancer pain mouse model^[3].

Animal Model:	Cancer pain mouse model ^[3]
Dosage:	3 mg/kg
Administration:	Injected subcutaneously at the site of the greatest tumor development
Result:	Attenuated cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection

IC 50

ET_B: 0.2 nM (IC₅₀)

storage

-20°C

References

[1] Arteaga JL,et.al. Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck. Neurourol Urodyn. 2012 Jun;31(5):688-94. DOI:10.1002/nau.22203
[2] Ihara M, et.al. A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors. Life Sci. 1992;51(6):PL47-52. DOI:10.1016/0024-3205(92)90418-o
[3] Quang PN, et.al. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain. 2010 May;149(2):254-262. DOI:10.1016/j.pain.2010.02.009

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