1427450-47-2

Name	2-((Z)-((E)-3-ethyl-5-(3-Methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)Methyl)-1-Methylpyridin-1-iuM 4-Methylbenzenesulfonate
CAS	1427450-47-2
Molecular Formula	C27H27N3O4S3
MDL Number	MFCD28386395
Molecular Weight	553.71
MOL File	1427450-47-2.mol

Synonyms

YM-01 Tosylate 2-((Z)-((E)-3-ethyl-5-(3-Methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)Methyl)-1-Methylpyridin-1-iuM 4-Methylbenzenesulfonate (2Z,5E)-3-ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-[(1-methylpyridin-1-ium-2-yl)methylidene]-1,3-thiazolidin-4-one:4-methylbenzenesulfonate

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Hazard Information

Description

YM-01 Tosylate is a potent antitumor agent, selectively targeting cancer cells and overcoming tamoxifen resistance.

Uses

HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC50 of 3.2 μM. HSP70-IN-4 is not BBB permeable[1].

in vivo

HSP70-IN-4 (Compound YM-01) cannot pass the blood-brain barrier^[1].

Animal Model:

CD1 mice^[1]

Dosage:

20 mg/kg

Administration:

Intravenous injection (Pharmacokinetic Analysis)

Result:

Initial pharmacokinetics of HSP70-IN-4 (Compound YM-01; 20 mg/kg; i.v.)^[1]

hour	plasma (ng/mL)	brain (ng/g)	kidney (ng/g)
0.16	359	0	74378
1	324	0	63231

IC 50

HSP70: 3.2 μM (IC₅₀)

References

[1] Miyata Y, et al. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. DOI:10.1021/cn300210g

Supplier

SPIRO PHARMA

Telephone

Websitehttp://www.spiropharma.com.cn

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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