1426174-79-9

Noroxycodone-d₃ (hydrochloride) (CRM) is intended for use as an internal standard for the quantification of noroxycodone by GC- or LC-MS. Noroxycodone is categorized as an opioid.^1,2 Noroxycodone is a metabolite of oxycodone .^3,4 This product is intended for research and forensic applications.

1. Leow, K.P., and Smith, M.T. The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats Life Sci. 54(17),1229-1236(1994).
2. Lalovic, B., Kharasch, E., Hoffer, C., et al. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites Clin. Pharmacol. Ther. 79(5),461-479(2006).
3. Romand, S., Spaggiari, D., Marsousi, N., et al. Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases J. Pharm. Biomed. Anal. 144,129-137(2017).
4. Fang, W.B., Lofwall, M.R., Walsh, S.L., et al. Determination of oxycodone, noroxycodone and oxymorphone by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry in human matrices: In vivo and in vitro applications J. Anal. Toxicol. 37(6),337-344(2013).