1425511-32-5

Luvadaxistat (TAK-831; 0.001-3 mg/kg/days; PO; 14 days) dose-dependently improves social behavior in the social interaction (SI) test in BALB/c animals with rodent models of negative symptoms of schizophrenia^[1].
Acute dosing of Luvadaxistat (0.3, 1, 3 mg/kg; p.o.) significantly reverses a poly(I:C)-induced deficit social preference in male C57BL/6 poly(I:C)-treated mice^[1].
Luvadaxistat (1, 3, 10 mg/kg; p.o. at 2, 6, 10, and 24 h) inhibits DAAO by increased rat cerebellar d-serine levels in a dose- and time-dependent manner with a maximal effect observed at a dose of 10 mg/kg at 10 h post-dose in male Wistar rats weighing 240-280 g^[1].