ChemicalBook CAS DataBase List 1422500-60-4

1422500-60-4

Name	N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine
CAS	1422500-60-4
Molecular Formula	C22H25N5O3S
Molecular Weight	439.53
MOL File	1422500-60-4.mol

Chemical Properties

Boiling point	745.4±70.0 °C(Predicted)
density	1.390±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 125 mg/mL (284.39 mM)
form	Solid
pka	7.70±0.20(Predicted)
color	White to off-white

Hazard Information

Spectrum Detail

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Dose (mg/kg)	AUC_0-24h(p.o.) (ng·h/mL)	CL (mL/min/kg)	T_1/2(i.v.) (h)	V_ss (L/kg)	F (%)
2 mg/kg (iv) or 10 mg/kg (po)	906	58	1.2	3.9	32

Dose (mg/kg)	AUC_0-24h(p.o.) (μg·h/L)	tissue/lasma AUC_0-24h ratio (μg·h/L)	T_1/2 (h)	T_max (h)	C_max (μg/L)
plasma	8,380	1	1.02	0.25	5090
lung	72,400	8.6	3.31	1	22700

Animal Model:	Female BALB/c mice infected by RSV^[1]
Dosage:	12.5 mg/kg, 50 mg/kg
Administration:	Oral gavage; twice daily; 4 days
Result:	Resulted >1 log unit of viral titer reduction in the lung of infected mice at the dose level as low as 12.5 mg/kg.? Reduced viral titer to 1.9 log units compared to vehicle at 50 mg/kg dose.

1422500-60-4

Chemical Properties

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in vivo

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References

Spectrum Detail

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