1416663-77-8

RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53.

RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively[1].

Store at -20°C

[1] Graves B, et al. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93. DOI:10.1073/pnas.1203789109