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Trans isomer of Clomiphene (C587025). Found to be slightly estrogenic and a less potent inhibitor of LH secretion than the cis isomer.

Trans isomer of Clomiphene (C587025). Found to be slightly estrogenic and a more potent inhibitor of LH secretion than the cis isomer.

Enclomiphene is a non-steroidal estrogen receptor antagonist th at promotes gonadotropin-dependent testosterone secretion by the testes. Enclomiphene is the trans-isomer of clomiphenewhich is about a 60-40 mix of trans (Enclomiphene) and cis (Zuclomiphene). While enclomiphene (trans-clomiphene) is an estrogen antagonistzuclomiphene (cis-clomiphene) is a mixed agonistresponsible for the estrogenic activity and therefore the common side effects sometimes seen in males. The enclomiphene isomer is responsible for the anti-estrogen activity and the restoration of ones hypothalamic–pituitary–gonadal axis. In recent clinical trialsenclomiphene increased serum LH and FSH with concomitant increases in testosterone in men with secondary hypogonadism. Enclomiphene showed overall better results than testosterone gelswhich raise serum testosterone but can lower LH and FSH at the same time.