MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.
References
[1] Martínez-González S, et al. Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors. ACS Med Chem Lett. 2021 Nov 2;12(11):1794-1801. DOI:10.1021/acsmedchemlett.1c00412
