1412458-61-7

Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

sPLA2: 2.5 nM (Ki); 5-HT_2A Receptor: 0.06 nM (Ki); 5-HT_2C Receptor: 0.03 nM (Ki); 5-HT₇ Receptor: 0.13 nM (Ki); D₂ Receptor: 1.3 nM (Ki); D₃ Receptor: 0.42 nM (Ki); D₄ Receptor: 1.1 nM (Ki)

Store at -20°C

[1] Stoner SC, Pace HA. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34(5):1023-40. DOI:10.1016/j.clinthera.2012.03.002
[2] Shahid M, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. DOI:10.1177/0269881107082944
[3] Ohyama M,et al. Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model. Acta Neuropsychiatr. 2016 Dec;28(6):327-336. DOI:10.1017/neu.2016.17
[4] Ene HM, et al. Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice. Acta Neuropsychiatr. 2016 Apr;28(2):85-91. DOI:10.1017/neu.2015.53