140926-75-6

NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC₅₀s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI₅₀ values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM.

N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine and other bisquinoline derivatives have potentials against chloroquine-resistant malaria. A useful intermediate for the preparation of other antimalarial bisaminoquinlines.

Plasmodium

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