ChemicalBook CAS DataBase List 1402452-10-1

1402452-10-1

Name	Benzenesulfonamide, N,N,2-trimethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-
CAS	1402452-10-1
Molecular Formula	C26H27N7O3S
Molecular Weight	517.6
MOL File	1402452-10-1.mol

Chemical Properties

storage temp.	4°C, away from moisture and light
solubility	DMSO : 50 mg/mL (96.60 mM; Need ultrasonic)
form	Solid
color	White to light yellow

Hazard Information

Uses

hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of <0.05 nM. hSMG-1 inhibitor 11e shows >900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM)[1].

Biological Activity

HSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with IC50 value <0.05 nM. hSMG-1 inhibitor 11e exhibits 900-fold selectivity for hSMG-1 over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50 of 61 nM and 92 nM) and CDK1/CDK2 (IC50 of 32 μM and 7.1 μM).

in vitro

HSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment.

target

mTOR

45 nM (IC ₅₀ )

PI3Kα

61 nM (IC ₅₀ )

PI3Kγ

92 nM (IC ₅₀ )

CDK1

32 μM ( IC ₅₀ )

CDK2

7.1 μM (IC ₅₀ )

hSMG-1

<0.05 nM (IC ₅₀ )

IC 50

hSMG-1: <0.05 nM (IC₅₀); mTOR: 45 nM (IC₅₀); PI3Kα: 61 nM (IC₅₀); PI3Kγ: 92 nM (IC₅₀); CDK1: 32 μM (IC₅₀); CDK2: 7.1 μM (IC₅₀)

storage

4°C, away from moisture and light

References

[1] Ariamala Gopalsamy, et al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41. DOI:10.1016/j.bmcl.2012.08.107

Spectrum Detail

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