Originator
Soripan,Specia,France,1970
Definition
ChEBI: Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group.
Manufacturing Process
10-Methyl-3-acetylphenthiazine is prepared in accordance with G. Cauquil and
A. Casadevall, Bull. Soc.Chim., p 768 (1955). (10-Methyl-3-phenthiazinyl)acetic acid (MP 146°C; 21.4 g) is prepared by Willgerodt's
reaction (action of sulfur and morpholine, followed by hydrolysis) employing
10-methyl-3-acetylphenthiazine as starting material.
Therapeutic Function
Antiinflammatory
Trade name
Roimal (Kantoishi, Japan),
Soripal (Torii, Japan).
Synthesis
Metiazinic acid is prepared via
the Willgerodt reaction (sulfur and morpholine)
from 2-acetyl-10-methylphenothiazine.
Dosage
Metiazinic acid has been beneficial to arthritis patients when given at a daily dose of
0.75 – 1.5 g/d.
